Triggering Factors Research Articles

Analysis of surface deformation and related factors over mining areas based on InSAR: A case study of Fengcheng mine

Abstract. Ground surface deformation in mines affects mining production, damages the ecological environment, and endangers human safety. Mastering the detailed time series deformation and related triggering factors can provide key information for the safety of the mining area. Therefore, the Fengcheng mining area, a large and ancient coal mine in Jiangxi Province, China, was selected as the study area in this work, and the following research was conducted: 1. The accuracy and applicability of the Stacking, Small-Baseline Subset InSAR (SBAS-InSAR), and Interferometric Point Target Analysis (IPTA) methods were preliminarily explored while monitoring the annual deformation rate based on Sentinel-1A data from October 2019 to November 2022. 2. The time-series deformation of the Fengcheng mining area was obtained with SBAS-InSAR technology, and the sedimentation was validated with leveling results. 3. The correlation factors of deformation, such as rainfall and land cover, were studied, and the relationship between the influencing factors, such as coal mining dip angle, digital elevation, coal mining elevation, and deformation, was quantitatively explored with the Grey correlation model and Pearson correlation analysis method. The following conclusions were drawn: The SBAS method has the best adaptability in the dense vegetation mining area, and the root-mean-square error of the difference between deformation results and leveling data does not exceed 4mm. The evolution process of deformation centers is mainly divided into the stages of initial deformation, constant velocity deformation, accelerated deformation, and stable condition. Compared with the natural factors, the settlement of the Fengcheng mining area is mainly affected by human-induced mining and construction of artificial facilities.

Acute heart failure and acute coronary syndrome: not uncommon duo and dangerous

Abstract Funding Acknowledgements None. Introduction Acute Heart Failure (AHF) is a common cause of hospitalisation. Its ethology and triggering factors influence the prognosis and evolution. Methods and purpose Retrospective analysis of 6330 patients admitted to our hospital's Coronary Care Unit (CCU) between 2012 and 2022. The main objective was to analyse the characteristics during hospital progress and follow-up of patients with AHF after an Acute Coronary Syndrome (ACS) in class Killip III or IV, comparing it with those admitted for AHF not secondary to ACS. Results 698 patients with AHF after ACS and 384 with AHF not secondary to ACS were included. 68.8% of patients presented Acute Coronary Syndrome with ST elevation (STEMI), with a higher prevalence in the anterior location (34,3%). Angioplasty was performed in 53.4% of patiens with STEMI and in 40.3% of patients with NSTEMI. The Cardiovascular risk factors (Figure 1) were similar in both groups, while patients with AHF not secondary to ACS had a history of Coronary Heart Disease (CHD) and atrial fibrilación (AF) more frequently. Patients with AHF after ACS more frequently required treatment with dobutamine and norepinephrine (63.6% and 57.6%, respectively) as well as orotracheal intubation. At the same time, levosimendan was administered more frequently to patients with AHF not secondary to ACS, with non-invasive mechanical ventilation being more frequent in this group. Both groups similarly received neurohormonal treatment, with beta-blockers being used the most. Events during follow-up (Figure 2) were higher in patients with AHF after ACS, except HF events. Cardiovascular mortality was 21.9% in patients with AHF after ACS. Conclusions Patients admitted for ACS complicated with AHF Killip III-IV represented 11.02%. The majority presented previously STEMI. During their admission, compared to patients admitted for AHF not secondary to ACS, they more frequently required vasoactive drugs and orotracheal intubation. Cardiovascular complications and mortality during follow-up were higher in patients with AHF after ACS. Therefore, early identification of patients with ACS at risk of developing AHF and establishing a specific and optimal treatment is crucial in the evolution of these patients.

FF-MAS prevents porcine ovarian granulosa cells from hypoxia-induced apoptosis via inhibiting STAT4 expression.

Follicular fluid meiosis-activating sterol (FF-MAS) is a small molecule compound found in follicular fluid, named for its ability to induce oocyte resumption of meiosis. Granulosa cells (GCs) within the follicle are typically located in a hypoxic environment under physiologic conditions due to limited vascular distribution. Previous research suggests that hypoxia-induced cell cycle arrest and apoptosis in GCs may be crucial triggering factors in porcine follicular atresia. However, the impact of FF-MAS on GCs within follicles has not been explored so far. In this study, we uncovered a novel role of FF-MAS in facilitating GC survival under hypoxic conditions by inhibiting STAT4 expression. We found that STAT4 expression was upregulated in porcine GCs exposed to 1% O2. Both gain and loss of function assays confirmed that STAT4 was required for cell apoptosis under hypoxia conditions, and that the GC apoptosis caused by hypoxia was markedly attenuated following FF-MAS treatment through inhibition of STAT4 expression. Correlation analysis in vivo revealed that GC apoptosis was associated with increased STAT4 expression, while the FF-MAS content in follicular fluid was negatively correlated with STAT4 mRNA levels and cell apoptosis. These findings elucidate a novel role of FF-MAS-mediated protection of GCs by inhibiting STAT4 expression under hypoxia, which might contribute to the mechanistic understanding of follicular development.

[Sequence variants of unknown significance in small fiber neuropathy : Characterization of a heterogeneous patient population].

In almost half of patients suffering from small fiber neuropathies (SFN), the etiology remains elusive. For these patients with "idiopathic SFN", symptomatic analgesic therapy is the only option. Reports on apotential genetic background of neuropathic pain syndromes are increasing and particularly in SFN patients, several genetic variants were found mainly located in genes encoding voltage-gated sodium channels. Although up to 30% of SFN patients show genetic alterations, most of these remain of "unknown pathogenic significance" and little is known about "genetic SFN". The study aimed to determine clinical characteristics of SFN patients carrying arare genetic variant of unknown significance in pain-associated genes. From 2015 to 2020, 66patients with primarily idiopathic SFN were examined and rare gene variants of unknown significance detected in 13/66 (20%) of these. Adetailed medical history with focus on pain was recorded and patients filled in standardized questionnaires to assess physical and emotional burden due to pain. The authors found 13/66 (20%) patients with rare variants of unknown significance located in pain-associated genes who reported pain refractory to analgesic treatment, ahigher number of external factors influencing clinical symptoms, and ahigher level of physical impairment and emotional stress due to pain compared with patients without such genetic variants. Early genetic assessment is recommended to optimize the management of patients with potentially hereditary SFN. Early access to rehabilitation and mental support as well as aconsequent elimination of external triggering factors should be granted.

Fenomena KDRT dan Praktik Mahar di Kampung Ndilek Lamba Leda, NTT

Various study attributes the bride-wealth culture as a significant factor in the prevalence of domestic violence (KDRT) in East Nusa Tenggara. This essay challenges the initial research findings by exploring the causes of instances of domestic abuse that took place in Ndilek Village, Lamba Leda District, NTT Province. The research employed a qualitative methodology, utilizing in-depth interviews as the primary means of data gathering. This study discovered that the bride-wealth culture within the Manggarai community in East Nusa Tenggara can potentially serve as the underlying cause of domestic violence, albeit only in specific circumstances. Furthermore, it is important to note that the mere practice of the bride-wealth culture does not necessarily result in violence within the marital household. Furthermore, there are several influential elements, apart from dowry, that contribute to domestic violence. These include economic circumstances, individual traits, extramarital affairs, gambling and alcohol abuse, as well as the level of maturity exhibited by the married couple. This study suggests that bride-wealth system can contribute to domestic violence, but it is not the primary factor. Several triggering factors unrelated to dowry have a more prominent role in situations of domestic violence. Due to this dichotomy, this study suggests that communities endorsing the tradition should effectively and equitably execute cultural customs to prevent them from becoming a catalyst for marital violence or other home issues. In addition, in order to completely eradicate domestic violence, it is crucial to effectively treat the underlying roots of this issue.

NATURE-BASED SOLUTIONS FOR REGULATING MOISTURE CONTENT IN AN EXPANSIVE CLAY SOIL

Land degradation in the form of mass movement is a major challenge in the humid tropics, where intense rainfall and tropical cyclones are common. Rainfall increases soil moisture content, which often acts as a triggering factor for mass movement events, particularly in clay soils with expansive minerals, where moisture changes impact structural integrity. Growing evidence suggests that Nature-based Solutions (NbS) can regulate soil moisture levels, which can assist in maintaining cohesion and hence reduce slope instability. This paper examines soil moisture changes due to Coconut Matting (CM), Coconut Matting-Natural Vegetation Hybrid (CMNV), Natural Vegetation (NV), and Vetiver grass (VET) and discusses moisture content regulation as it relates to slope stability, with a particular focus on expansive clays. Soil moisture trends were measured for 90 days at four depths (20cm, 40cm, 60cm, and 100cm) using soil moisture loggers, while precipitation levels were monitored using a rain gauge. GLM ANOVA analysis showed a significant depth*treatment interaction (P<0.05) on soil moisture. The Vetiver grass treatment had the lowest soil moisture levels, with a (27.62%) reduction compared to the control (bare plot). The CMNV treatment had the second-greatest % soil moisture reduction (7.68%). Conversely, CM and NV resulted in limited moisture reduction (1.99%) and (0.73%) respectively. The role of Vetiver grass was therefore highlighted in mitigating water saturation towards preventing potential slope instability.

Are Chiari malformation and basilar invagination associated with jugular foramen stenosis?

ObjectiveTo compare the diameter of the jugular foramen (JF) between normal individuals and those with the diagnosis of craniovertebral junction abnormalities, such as Chiari malformation type I (CMI) and/or basilar invagination (BI). MethodsThis cross-sectional analytical study measured the diameter of right and left JF in magnetic resonance imaging of patients that were split into four groups: 68 with combined CMI and BI (CMI+BI), 42 with isolated BI, 45 with isolated CMI, and 102 control cases. The t test determined sex differences, while univariate ANOVA with Tukey's post-hoc test assessed JF differences between groups. ResultsConsidering all combinations of laterality and sex, CMI+BI had JF narrower than their respective controls. The JF was bilaterally narrower in BI than the control, only in females. Regardless of laterality, CMI had wider JF than the CMI+BI in males, and it did not differ from the control. In the females of CMI, the right JF did not differ from the control, and it was wider than the CMI+BI; while the left JF was narrower than the control, and it did not differ from the CMI+BI. ConclusionJF narrowing is associated with CMI and BI when they are found combined in the same patient. When CMI or BI are detected separately, they do not imply evident changes in JF morphometry. It is expected that these findings could bring empiric substrate to support theories that claims a possible role of intracranial pressure disturbances as a triggering factor for CMI.

Entecavir induced gynecomastia- Triggering factor or coincidence?

Entecavir is an important nucleoside analogue that plays a pivotal role in the treatment of Hepatitis B infection. In this case report, it was aimed to present a case regarding bilateral gynecomastia and mastodonia while receiving entecavir treatment.

Thyroid storm: Report of four cases in two health institutions, Barranquilla

Thyroid storm or thyrotoxic crisis is a life-threatening condition, characterized by signs and symptoms of thyrotoxicosis associated with multiorgan dysfunction, occurs as a complication of hyperthyroidism and due to its high risk of mortality, merits timely diagnosis and early treatment. Among the main causes of thyroid storm is Graves' Basedow's disease, which is associated with triggering factors such as non-adherence to medical therapy. The diagnosis is based on clinical manifestations and increased thyroid hormones, but thyroid hormone levels are not related to the severity of the condition, so sensitive scoring systems have been developed to support the diagnostic approach. In this review, we analyze a series of patients with thyroid storm in which half of the patients have a fatal outcome, demonstrating the association with high mortality.

CONCEPT OF AGNI IN ATHEROSCLEROSIS AND ITS MANAGEMENT THROUGH YOGA&amp; AYURVEDA

In Ayurveda, the concept of Agni is inevitable in determining the overall health of an individual, where Agni is said to be the base (moola) of life. The whole catabolic and metabolic processes are carried out in human body, regulated by Agni .But if due to Pragyaparadh or faulty lifestyle, the Agni is deranged then the metabolic activity becomes disturbed at cellular tissue and organ level and it fascilitates to the formation of Ama. Hence, Ama is a triggering factor of many diseases that in turn destroys the Agni. Atherosclerosis occurs mainly due to lifestyle abnormality which is a direct result of Ama accumulation in the body. It is observed that 17.7 million people die each year from Cardiovascular Disorders, in which Atherosclerosis is the precipitating factor and an estimated 31% of all deaths worldwide (acc to WHO). Atherosclerosis is a condition where the arteries become narrowed and hardened due to a build up of Plaque around the artery wall. This disease disrupts the flow of blood around the body, posing the risk of serious complications. The term ‘Atherosclerosis’ is derived from the Greek word ‘athero’ meaning gruel or wax corresponding to the necrotic core area at the base of atherosclerotic plaque and ‘sclerosis’ for hardening the plaques luminal edge. Apart from drug, Yoga therapy may play a pivotal role for alleviation of Atherosclerosis. Yoga therapy improves the blood flow to the organs by neuromuscular action. Practice of Pranayama stimulates and changes the lumen size of the arterioles, which helps to regulate the circulation.

A study to assess the prevalence and pattern of internet addiction among medical students in Patna, Bihar

A study to assess the prevalence and pattern of internet addiction among medical students in Patna, Bihar

Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease.

Hepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact the brain. However, the role of alcohol in the development of HE in CLD remains unclear. Here, we investigated the impact of excessive alcohol administration on neurological deterioration in rats with CLD. Starting day 7 post-BDL surgery, rats were administered alcohol twice daily (51% v/v ethanol, 3 g/kg, via gavage) for 4 weeks. Motor coordination was assessed weekly using rotarod and anxiety-like behavior was evaluated with open field and elevated plus maze at 5 weeks. Upon sacrifice, brains were collected for western blot and immunohistochemical analyses to investigate neuronal integrity and oxidative stress status. Alcohol worsened motor coordination performance and increased anxiety-like behavior in BDL rats. Impairments were associated with decreased neuronal markers of NeuN and SMI311, increased apoptotic markers of cleaved/pro-caspase-3 and Bax/Bcl2, increased necroptosis markers of pRIP3 and pMLKL, decreased total antioxidant capacity (TAC), and increased 4-hydroxynonenal (4-HNE)modified proteins in the cerebellum of BDL-alcohol rats when compared to respective controls. Immunofluorescence confirmed the colocalization of cleaved caspase-3 and pMLKL in the granular neurons of the cerebellum of BDL-alcohol rats. Excessive alcohol consumption exacerbates HE which leads to associated apoptotic and necroptotic neuronal loss in the cerebellum of BDL-alcohol rats. Additionally, higher levels of 4-HNE and decreased TAC in the cerebellum of BDL-alcohol rats suggest oxidative stress is the triggering factor of apoptotic and necroptotic neuronal loss/injury.

PHYSIOLOGICAL ACTIVITY ANALYSIS AND GROWTH OF EBONY SEEDLINGS (Diospyros celebica Bakh) TREATED BY VARIOUS BIOFERTILIZER COMBINATIONS

Ebony is one of slow-growing spe- cies), that of suspected to be the triggering factors to prone to extinction. In addition, the nature of ebony seeds is recalcitrant, so they cannot be stored for a long time. Other factors affecting seed germination are the degree of maturity, size, and weight of the seeds. Seeds harvested before the physiological maturity level would not have high viability and even could not germinate well due to the in-sufficient of food reserves, and un-perfect embryo formatio. Bio-fertilizer is used to help accelerate the growth of ebony. This study aims to analyze the combination of bio fertilizers which would be giving a better effect on the physiological activity and growth of ebony seedlings. Morphological and physiological variables measurement were used in this study. The research design used a Completely Randomized Design at a real level of 5%. If the fingerprint results obtained have a real effect, then a further test of the Duncan Multiple Range Test is carried out. Re- search results showed that seed coating treatment of 45% Penicillium microbial solution + seed coating) gave the best results in each variable of both growth and physiology of ebony seedlings, while in the treatment without seed coating, Sargassum microbial solution 30% indicates good results in each variable of growth and physiology of ebony seedlings. Treatment with the immersion of seeds in microbes can produce a high percentage in each variable.

Exploring the Potential Consortium of Migraine and Periodontitis.

Various researches have shown periodontitis to share common pathophysiological pathways with systemic diseases such as diabetes, cardiovascular diseases, and osteoporosis and recently neurological disorders. This article provides a narrative review summarizing the various linking mechanisms and the nature of association between two multifactorial diseases-periodontitis and migraine. A literature search was performed for articles related to periodontitis and migraine up till the year 2023 which yielded totally 14 articles. There were only three randomized controlled clinical trials; therefore, we were unable to conduct a systematic review and focused on a narrative review. The keywords searched were "migraine", "periodontitis" and "biomarkers" in PubMed/Medline, Web of Science, and Embase databases. Any article related to the association of periodontitis and migraine and the dental management of subjects with headache disorders were included and studies with migraine and other dental diseases were excluded. It is found that the occurrence of periodontitis and migraine are associated with each other. There is reasonable evidence to believe that periodontitis and migraine are linked by direct and indirect mechanisms which can eventually lead to chronic inflammatory conditions like periodontitis worsening neurovascular conditions such as migraine. However, upon detailed analysis it was found that the strength of association is weak owing to the presences of various common confounding and risk factors. The association between periodontitis and migraine cannot be denied, however, not all the criteria are fulfilled while examining the nature of association and future long-term studies are required to prove the same. Clinical Relevance. Various studies have reported poor periodontal health in patients with migraine. The risk of exacerbation of migraine also increases in subject undergoing dental therapy if the triggering factors are manipulated. Hence, knowing the precise pathophysiologic mechanisms linking both the diseases would be favorable in planning treatment protocols for subjects with migraine.

Pouchitis: pathophysiology and management.

Pouchitis is an acute or chronic inflammatory disease of the ileal reservoir. It is common after restorative proctocolectomy with ileal pouch-anal anastomosis, and treatment of chronic antibiotic-refractory pouchitis has proven challenging. Most cases of acute pouchitis evolve into chronic pouchitis. The aetiology of acute pouchitis is likely to be partly related to the gut microbiota, whereas the pathophysiology of chronic pouchitis involves abnormal interactions between genetic disposition, faecal stasis, the gut microbiota, dysregulated host immunity, surgical techniques, ischaemia and mesentery-related factors. Pouchoscopy with biopsy is the most valuable modality for diagnosis, disease monitoring, assessment of treatment response, dysplasia surveillance and delivery of endoscopic therapy. Triggering or risk factors, such as Clostridioides difficile infection and use of non-steroidal anti-inflammatory drugs, should be modified or eradicated. In terms of treatment, acute pouchitis usually responds to oral antibiotics, whereas chronic antibiotic-refractory pouchitis often requires induction and maintenance therapy with integrin, interleukin or tumour necrosis factor inhibitors. Chronic pouchitis with ischaemic features, fistulae or abscesses can be treated with hyperbaric oxygen therapy.

Creation of ‘other’ in their own country, politicized identity-based division, and the rise of hostility toward ‘out-group’ in a multi-ethnic, poly-cultural world: a study on genocide prevention, human security, and peacebuilding

ABSTRACT In the era of globalization, no country is monocultural today. All countries are cultural mosaics since different ethnic groups have their own unique set of traditions. It is particularly important to appreciate and respect these traditions since they represent an integral part of our cultural heritage. Likewise, in many countries, the majority population is far greater than all the minorities combined, whereas, in others, the minority groups all together comprise a significantly large number. In this increasingly integrated yet fragmented world, many multi-ethnic countries face the challenges of preventing cultural conflicts between diverse groups and finding solutions. A fresh wave of persecution and violence against minority groups for their membership in a pluralistic society has escalated in many parts of the world, altering the climate of peaceful coexistence and democratic oversight. Such challenges are particularly pressing for marginalized, vulnerable groups. The article endeavors to foster a more holistic interpretation of the questions: why do some regions of the world experience major incidents of ‘crimes against humanity' and gross human rights violations while others do not, and how do the ‘us vs. them’ politics, politicians, and other leaders subtly transform civilians into killers? The article also examines the triggering factors of major tragedies, particularly what sets off acts of ethnic cleansing or genocide. As such, exploring the demagogues’ malicious mission to subvert justice, democratic success, and the rule of law, creating destructive cultures on the path to mass atrocities, is the additional emphasis of this piece. This entry’s relevance depends on the quest for the conditions and prospects for conflict transformation, peacebuilding, and peaceful cohabitation across different cultural traditions in the changing socio-political and cultural milieu owing to contemporary global shifts to authoritarianism and illiberal populism.

0656 Severe Air Pollution as a Possible Triggering Factor for Kleine-levin Syndrome

0656 Severe Air Pollution as a Possible Triggering Factor for Kleine-levin Syndrome

Clinical and laboratory spectrum of hereditary angioedema in a group of Egyptian children: a cross sectional study

BackgroundHereditary angioedema (HAE) is a hereditary illness represented by repeated bouts of submucosal or subcutaneous edema. Types of HAE includes; HAE with deficient C1-inhibitor (type 1), HAE with dysfunctional C1-inhibitor (type 2), and HAE with normal C1-inhibitor. Data on the epidemiology of HAE in Egypt are limited. Therefore, we aimed to characterize HAE in Egyptian children, identify the morbidity, and clarify HAE's different clinical and laboratory presentations.MethodsIn this cross-sectional study, we enrolled pediatric patients diagnosed with HAE according to the international hereditary angioedema WAO/EAACI guidelines. We gathered laboratory data on patients' mean serum C1 esterase inhibitor (C1-INH) level and activity, C4, and IgE levels.ResultsWe included 18 HAE patients (14 females and 4 males). They were between the ages of 6 and 18 years. The mean age upon confirmation of diagnosis was 8.4 ± 2.4 years. The mean time required to correctly diagnose HAE was 3.2 ± 1.8 years. We detected type I in 15 cases and type II in three cases. Eleven patients had a family member with HAE. In terms of previous misdiagnoses, 50% of patients were diagnosed with allergic angioedema. The median annual frequency of episodes was 17. The mean HAE attack time was 2.9 ± 1.5 days. Edema was most typically found in the face and abdomen. Trauma was the main triggering factor. We detected a significant direct relationship between severity of attack and C1-INH activity level.ConclusionsThis research adds a considerable clinical information about children with HAE. According to current results, there is a considerable underdiagnosis of HAE in Egypt. The detection and management of HAE can be improved by screening the relatives of HAE patients.

Triggering factors affecting primary school children in Lebanon: A pilot cross-sectional study

Purpose: Academic pressures, the fear of failure, social expectations, and high expectations from parents or teachers can all contribute to performance-related stress or anxiety in children. This study aims to assess the triggers encountered by primary schoolchildren and examine the interrelatedness between them and the characteristics of the students. Methods: A pilot cross-sectional study targeted primary school children over two months. Two pharmacists and a psychologist collected data using a standardized survey. Students were asked to assess their social (10 statements), behavioral (10 statements), environmental (10 statements), and academic (16 statements) triggers. Results: Environmental triggers had the highest score (4.92 (1.92)), followed by behavioral triggers (4.21 (1.70)). Social triggers were the least reported (3.52 (1.59)). After adjusting for covariates, age, sex, and grade did not affect the academic triggers of the students (p &gt; 0.05), while having divorced or separated parents significantly increased these triggers (B = 0.22; p = 0.025). The social triggers and stressors significantly decreased (B = −0.28; p = 0.003) per grade increase. In contrast, having divorced parents significantly increased these scores (B = 0.21; p = 0.025). Environmental triggers significantly decreased per increase of one year in age (B = −0.23; p = 0.013), with the same pattern observed for the overall trigger scores (B = −0.28; p = 0.003). Conclusion: Promoting open communication, creating an inclusive environment establishing achievable academic goals, and regular follow-up with students can be effective strategies to reduce school triggers among those at high risk.

Exploring the spectrum of vitiligo: Clinical and demographic perspectives – A cross-sectional study

Objectives: Vitiligo is an acquired depigmentation skin disorder caused by the progressive loss of melanocytes and melanin, characterized by white macules on the skin. This study aimed to understand a specific population’s demographic and clinical characteristic factors associated with vitiligo. Materials and Methods: This cross-sectional study consists of 50 patients undergoing treatment for vitiligo at the RSV Clinic, Chennai, for a period of six months. Our study included comprehensive sociodemographic, clinical, and vitiligo profile examinations. Vitiligo disease activity score and vitiligo area scoring index were assessed in all patients, and their treatment approaches were noted. Results: The results showed that vitiligo was most common in adolescents and young adults (66%), followed by children under 10 (18%) and adults over 50 (20%). There was a nearly equal gender distribution, with 52% females and 48% males. Education levels varied, and no specific association with vitiligo was found. The onset of symptoms ranged widely, with lips (28%) and face other than lips (24%) as common initial sites. Coexisting conditions included premature canities (10%) and psoriasis (6%). Treatment approaches varied, with 26% undergoing topical steroids and other therapies. Various triggers were identified, such as trauma (10%) and stress (6%). Clinical manifestations included leukotrichia (18%) and trichrome lesions (10%). Conclusion: This study confirms vitiligo’s prevalence in adolescents and young adults, emphasizing its link to autoimmune disorders. It also underscores complex triggering factors and diverse clinical manifestations among those with vitiligo, enhancing our understanding of its demographics and clinical characteristics in this population.